Decompressive Craniectomy in Diffuse Traumatic Brain Injury
D James Cooper, Jeffrey V Rosenfeld, Lynnette Murray, Yaseen M Arabi, Andrew R Davies, Paul D'Urso, Thomas Kossmann, Jennie Ponsford, Ian Seppelt, Peter Reilly, Rory Wolfe
New England Journal of Medicine | MASSACHUSETTS MEDICAL SOC | Published : 2011
BACKGROUND: It is unclear whether decompressive craniectomy improves the functional outcome in patients with severe traumatic brain injury and refractory raised intracranial pressure. METHODS: From December 2002 through April 2010, we randomly assigned 155 adults with severe diffuse traumatic brain injury and intracranial hypertension that was refractory to first-tier therapies to undergo either bifrontotemporoparietal decompressive craniectomy or standard care. The original primary outcome was an unfavorable outcome (a composite of death, vegetative state, or severe disability), as evaluated on the Extended Glasgow Outcome Scale 6 months after the injury. The final primary outcome was the s..View full abstract
Awarded by National Health and Medical Research Council of Australia
Supported by grants from the National Health and Medical Research Council of Australia (NHMRC 314502), the Transport Accident Commission of Victoria (Victorian Trauma Foundation and Victorian Neurotrauma Initiative), the Intensive Care Foundation (Australia), and the Western Australian Institute for Medical Research.