Journal article

Whole-Body Hypothermia for Term and Near-Term Newborns With Hypoxic-Ischemic Encephalopathy A Randomized Controlled Trial

Susan E Jacobs, Colin J Morley, Terrie E Inder, Michael J Stewart, Katherine R Smith, Patrick J McNamara, Ian MR Wright, Haresh M Kirpalani, Brian A Darlow, Lex W Doyle

Archives of Pediatrics & Adolescent Medicine | AMER MEDICAL ASSOC | Published : 2011


OBJECTIVE: To determine the effectiveness and safety of moderate whole-body hypothermia in newborns with hypoxic-ischemic encephalopathy born in hospitals with and without newborn intensive care facilities or complicated hypothermia equipment. DESIGN: Multicenter, international, randomized controlled trial. SETTING: Neonatal intensive care units in Australia, New Zealand, Canada, and the United States (N = 28) from February 2001 through July 2007. PARTICIPANTS: Newborns of 35 weeks' gestation or more, with indicators of peripartum hypoxia-ischemia and moderate to severe clinical encephalopathy, randomly allocated to hypothermia (n = 110) or standard care (n = 111). INTERVENTION: Whole-body h..

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