Whole-Body Hypothermia for Term and Near-Term Newborns With Hypoxic-Ischemic Encephalopathy A Randomized Controlled Trial
Susan E Jacobs, Colin J Morley, Terrie E Inder, Michael J Stewart, Katherine R Smith, Patrick J McNamara, Ian MR Wright, Haresh M Kirpalani, Brian A Darlow, Lex W Doyle
Archives of Pediatrics & Adolescent Medicine | AMER MEDICAL ASSOC | Published : 2011
OBJECTIVE: To determine the effectiveness and safety of moderate whole-body hypothermia in newborns with hypoxic-ischemic encephalopathy born in hospitals with and without newborn intensive care facilities or complicated hypothermia equipment. DESIGN: Multicenter, international, randomized controlled trial. SETTING: Neonatal intensive care units in Australia, New Zealand, Canada, and the United States (N = 28) from February 2001 through July 2007. PARTICIPANTS: Newborns of 35 weeks' gestation or more, with indicators of peripartum hypoxia-ischemia and moderate to severe clinical encephalopathy, randomly allocated to hypothermia (n = 110) or standard care (n = 111). INTERVENTION: Whole-body h..View full abstract
Awarded by Australian National Health and Medical Research Council
This study was supported by project grant 216725 from the Australian National Health and Medical Research Council and by the Royal Women's Hospital Foundation.