Journal article
Association of plasma Aß peptides with blood pressure in the elderly
JC Lambert, J Dallongeville, KA Ellis, S Schraen-Maschke, J Lui, S Laws, J Dumont, F Richard, D Cottel, C Berr, D Ames, CL Masters, CC Rowe, C Szoeke, C Tzourio, JF Dartigues, L Buée, R Martins, P Amouyel
Plos One | Published : 2011
Abstract
Background: Aß peptides are often considered as catabolic by-products of the amyloid ß protein precursor (APP), with unknown physiological functions. However, several biological properties have been tentatively attributed to these peptides, including a role in vasomotion. We assess whether plasma Aß peptide levels might be associated with systolic and diastolic blood pressure values (SBP and DBP, respectively). Methodology/Principal Findings: Plasma Aß1-40 and Aß1-42 levels were measured using an xMAP-based assay in 1,972 individuals (none of whom were taking antihypertensive drugs) from 3 independent studies: the French population-based 3C and MONA-LISA (Lille) studies (n = 627 and n = 769,..
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Awarded by INSERM-DHOS-INCA
Awarded by European Community
Funding Acknowledgements
The 3C Study was performed as part of a collaboration between the Institut National de la Sante et de la Recherche Medicale (INSERM), the Victor Segalen-Bordeaux II University and Sanofi-Synthelabo. The Fondation pour la Recherche Medicale funded the preparation and initiation of the study. The 3C Study was also funded by the Caisse Nationale Maladie des Travailleurs Salaries, Direction Generale de la Sante, MGEN, Institut de la Longevite, Agence Francaise de Securite Sanitaire des Produits de Sante, the Aquitaine and Bourgogne Regional Councils, Fondation de France and the joint French Ministry of Research/INSERM "Cohortes et collections de donnees biologiques" programme. Sanofi-Synthelabo provided funding for this study. Lille Genopole received an unconditional grant from Eisai. This work was additionally funded by the CNRS, the Nord Pas-de-Calais Regional Council, the European Regional Development Fund and grants from INSERM-DHOS-INCA (Project A08037ECS) and the European Community's cNEUPRO programme (contract LSHM-CT-2007-037950). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.