Journal article
NeOProM: Neonatal Oxygenation Prospective Meta-analysis Collaboration study protocol
Lisa M Askie, Peter Brocklehurst, Brian A Darlow, Neil Finer, Barbara Schmidt, William Tarnow-Mordi
BMC PEDIATRICS | BMC | Published : 2011
Open access
Abstract
BACKGROUND: The appropriate level of oxygenation for extremely preterm neonates (<28 weeks' gestation) to maximise the greatest chance of survival, without incurring significant morbidity, remains unknown. Infants exposed to lower levels of oxygen (targeting oxygen saturations of 90%) have been reported to have greater rates of morbidity including retinopathy of prematurity and chronic lung disease. In order to answer this clinical dilemma reliably, large scale trial evidence is needed. METHODS/DESIGN: To detect a small but important 4% increase in death or severe disability in survivors, over 5000 neonates would need to be recruited. As extreme prematurity affects 1% of births, such a proje..
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Funding Acknowledgements
Members of the NeOProM Collaborative Group who have contributed to the development of this protocol (in alphabetical order): Lisa M Askie, Peter Brocklehurst, Wally Carlo, Cynthia Cole, Lorrie Costantini, Brian A Darlow, Abhik Das, Peter Davis, Lex Doyle, Neil Finer, Marie Gantz, Henry Halliday, Edmund Hey, Rosemary Higgins, Neil Marlow, Colin Morley, Wade Rich, Robin Roberts, Barbara Schmidt, John Simes, Ben Stenson, William Tarnow-Mordi, Jayne F Tierney, Win Tin, Kris Zaterka-Baxter. We would also like to acknowledge the funding support of the NHMRC Clinical Trials Centre, University of Sydney, Australian National Health and Medical Research Council, The Health Research Council of New Zealand, The National Institutes of Health (USA) and the Canadian Institutes of Health Research; Kylie Hunter and Charlene Thornton for research assistant support; David Henderson-Smart, Jack Sinclair, Gabriel Duc and the late Bill Silverman and Edmund Hey for their wise counsel on this topic over many years.