Atypical antipsychotics cause an acute increase in cutaneous hand blood flow in patients with schizophrenia and schizoaffective disorder

E Blessing; L Kader; R Arpandy; Y Ootsuka; WW Blessing; C Pantelis

Journal article

Atypical antipsychotics cause an acute increase in cutaneous hand blood flow in patients with schizophrenia and schizoaffective disorder

E Blessing, L Kader, R Arpandy, Y Ootsuka, WW Blessing, C Pantelis

Australian and New Zealand Journal of Psychiatry | SAGE PUBLICATIONS LTD | Published : 2011

DOI: 10.3109/00048674.2011.587397

Abstract

Objective: Clinical studies suggest resting thermoregulatory cutaneous vasomotor tone could be increased in schizophrenia, resulting in reduced hand blood flow. In animal models, atypical antipsychotics including clozapine potently inhibit sympathetic neural outflow to the thermoregulatory cutaneous vascular beds. We have now determined whether antipsychotic medication administration is associated with an acute increase in hand blood flow in patients with schizophrenia and schizoaffective disorder, and whether this increase correlates with clinical status. Method: Hand temperature was measured with an infrared camera in 12 patients with chronic schizophrenia or schizoaffective disorder 30 mi..

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University of Melbourne Researchers

Christos Pantelis Author

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Grants

Awarded by NHMRC

Funding Acknowledgements

Reza Arpandy undertook this work as part of his Advanced Medical Science thesis completed in 2008. William Blessing was supported by NHMRC Senior Principal Research Fellowship (480408). Christos Pantelis was supported by a NHMRC Senior Principal Research Fellowship (ID: 628386) and NHMRC Program Grants (ID: 566529). In the last five years, Christos Pantelis has received grant support from Janssen-Cilag, Eli Lilly, Hospira (Mayne), Astra Zeneca. He has provided consultancy to Janssen-Cilag, Eli Lilly, Hospira (Mayne), Astra Zeneca, Pfizer, Schering Plough, Lundbeck. The study was supported by the clinical team at the Adult Mental Health Rehabilitation Unit (AMHRU), Sunshine Hospital, St. Albans, Australia. The equipment to assess hand temperature was supported by a grant to William Blessing from Flinders Medical Centre Research Foundation.