Fiber geometry in the corpus callosum in schizophrenia: Evidence for transcallosal misconnection

TJ Whitford; P Savadjiev; M Kubicki; LJ O'Donnell; DP Terry; S Bouix; CF Westin; JS Schneiderman; L Bobrow; AC Rausch; M Niznikiewicz; PG Nestor; C Pantelis; SJ Wood; RW McCarley; ME Shenton

Journal article

Fiber geometry in the corpus callosum in schizophrenia: Evidence for transcallosal misconnection

TJ Whitford, P Savadjiev, M Kubicki, LJ O'Donnell, DP Terry, S Bouix, CF Westin, JS Schneiderman, L Bobrow, AC Rausch, M Niznikiewicz, PG Nestor, C Pantelis, SJ Wood, RW McCarley, ME Shenton

Schizophrenia Research | ELSEVIER SCIENCE BV | Published : 2011

DOI: 10.1016/j.schres.2011.07.010

Abstract

Background: Structural abnormalities in the callosal fibers connecting the heteromodal association areas of the prefrontal and temporoparietal cortices bilaterally have been suggested to play a role in the etiology of schizophrenia. Aims: To investigate for geometric abnormalities in these callosal fibers in schizophrenia patients by using a novel Diffusion-Tensor Imaging (DTI) metric of fiber geometry named Shape-Normalized Dispersion (SHD). Methods: DTIs (3T, 51 gradient directions, 1.7. mm isotropic voxels) were acquired from 26 schizophrenia patients and 23 matched healthy controls. The prefrontal and temporoparietal fibers of the corpus callosum were extracted by means of whole-brain tr..

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University of Melbourne Researchers

Thomas Whitford Author

Christos Pantelis Author

Stephen Wood Author

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Grants

Awarded by National Institutes of Health

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia (520627 to TW; 359223 and 628711 to SW; 628386, 350241 and 566529 to CP), the National Institutes of Health (R03 MH068464-0 and U54 EB005149 to MK; R25 CA089017-06A2 to LOD; RO1 MH 082918 to SB; T32 MH 016259 to JS; R01 MH 074794 and P41 RR 013218 to CFW; K05 MH 070047, R01 MH 50747 and U54 EB005149 to MES; MH 040799 to RWM; the Boston Center for Intervention Development and Applied Research - CIDAR, P50 MH 080272 to RWM and MES), the Department of Veterans Affairs (VA Merit Awards, and VA Schizophrenia Research Center Grants to MES and RWM), Harvard Medical School (Milton Award to MK), the Center for Integration of Medicine and Innovative Technology Soldier in Medicine Award (grant to SB), and the NARSAD Brain and Behavior Research Fund (NARSAD 17537 to TW).