Journal article

Volumetric Abnormalities Predating the Onset of Schizophrenia and Affective Psychoses: An MRI Study in Subjects at Ultrahigh Risk of Psychosis

Paola Dazzan, Bridget Soulsby, Andrea Mechelli, Stephen J Wood, Dennis Velakoulis, Lisa J Phillips, Alison R Yung, Xavier Chitnis, Ashleigh Lin, Robin M Murray, Patrick D McGorry, Philip K McGuire, Christos Pantelis



It remains unclear whether brain structural abnormalities observed before the onset of psychosis are specific to schizophrenia or are common to all psychotic disorders. This study aimed to measure regional gray matter volume prior to the onset of schizophreniform and of affective psychoses. We investigated 102 subjects at ultrahigh risk (UHR) of developing psychosis recruited from the Personal Assessment and Crisis Evaluation Clinic in Melbourne, Australia. Twenty-eight of these subjects developed psychosis subsequent to scanning: 19 schizophrenia, 7 affective psychoses, and 2 other psychoses. We examined regional gray matter volume using 1.5 mm thick, coronal, 1.5 Tesla magnetic resonance i..

View full abstract


Awarded by National Health and the Medical Research Council (NHMRC)

Funding Acknowledgements

Project grants from the National Health and the Medical Research Council (NHMRC Project grant numbers: 970598, 970391, 981112; NHMRC Program Grant numbers: 350241,566529); Victorian Health Promotion Foundation; Stanley Foundation; Ian Potter Foundation; Woods Family Trust; Australian Communications and Computing Institute; Percy Baxter Charitable Trust; NARSAD. Also, support from the NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, Kings College London, a Short-Term Travel Grant from the Wellcome Trust; a grant from the University of London; a NARSAD Independent Investigator Award (to Dr. P. Dazzan); a Clinical Career Development Award from the NHMRC and a NARSAD Young Investigator Award (to A/Prof Wood); a NARSAD Independent Investigator Award (to Dr. A. Mechelli). The funders had no role in design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.