Journal article
Diffusion Tensor Imaging in Huntington's disease reveals distinct patterns of white matter degeneration associated with motor and cognitive deficits
I Bohanna, N Georgiou-Karistianis, A Sritharan, H Asadi, L Johnston, A Churchyard, G Egan
Brain Imaging and Behavior | Published : 2011
Abstract
White matter (WM) degeneration is an important feature of Huntington's disease (HD) neuropathology. To investigate WM degeneration we used Diffusion Tensor Imaging and Tract-Based Spatial Statistics to compare Fractional Anisotropy, Mean Diffusivity (MD), parallel diffusivity and perpendicular diffusivity (λ⊥) in WM throughout the whole brain in 17 clinically diagnosed HD patients and 16 matched controls. Significant WM diffusivity abnormalities were identified primarily in the corpus callosum (CC) and external/extreme capsules in HD patients compared to controls. Significant correlations were observed between motor symptoms and MD in the CC body, and between global cognitive impairment and ..
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Funding Acknowledgements
This study was funded by grant number 234247 from the National Health and Medical Research Council (Australia). We sincerely thank all participants for their time and effort. We also thank the Brain Research Institute (Austin Hospital) for the use of the 3T GE scanner. This study was carried out at School of Psychology, Psychiatry and Psychological Medicine, Monash University, Clayton, Victoria 3800, Australia. IB is supported by an Australian Rotary Health scholarship.