Journal article
Advanced glycation urinary protein-bound biomarkers and severity of diabetic nephropathy in man
MT Coughlan, SK Patel, G Jerums, SA Penfold, TV Nguyen, KC Sourris, S Panagiotopoulos, PM Srivastava, ME Cooper, LM Burrell, RJ MacIsaac, JM Forbes
American Journal of Nephrology | Published : 2011
DOI: 10.1159/000331064
Abstract
Background/Aims: The formation of advanced glycation end products (AGEs) is accelerated in patients with diabetic nephropathy. The aim of this study was to ascertain if the urinary excretion of proteins modified by advanced glycation can be used as biomarkers for albuminuria in individuals with type 1 or type 2 diabetes. Methods: Community-based patients with type 1 (n = 68) or type 2 diabetes (n = 216) attending a diabetes clinic of a tertiary referral hospital were classified as having normoalbuminuria (Normo, albumin excretion rate (AER) <20 μg/min), microalbuminuria (Micro, AER 20-200 μg/min) or macroalbuminuria (Macro, AER ≥200 μg/min). Serum and urine AGE-modified proteins were measure..
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Awarded by National Heart, Lung, and Blood Institute
Funding Acknowledgements
The authors would like to thank Trudy Smith and Aysel Akdeniz for the collection of the serum samples and Amy Morley, Felicia Yap and Karey Cheong for their technical support. This research was funded by a Juvenile Diabetes Research Foundation (JDRF) Centre Grant (4-2004-804 Proj 4) and a grant from the National Institutes of Health (ROI-HLO83452-01). M.T.C. is supported by an Australian Diabetes Society Early Career Fellowship. J.F. is in receipt of an NHMRC Fellowship. Supported in part by the Victorian Government's Operational Infrastructure Support Program.