Osteocyte Wnt/beta-Catenin Signaling Is Required for Normal Bone Homeostasis
Ina Kramer, Christine Halleux, Hansjoerg Keller, Marco Pegurri, Jonathan H Gooi, Patricia Brander Weber, Jian Q Feng, Lynda F Bonewald, Michaela Kneissel
MOLECULAR AND CELLULAR BIOLOGY | AMER SOC MICROBIOLOGY | Published : 2010
Beta-Catenin-dependent canonical Wnt signaling plays an important role in bone metabolism by controlling differentiation of bone-forming osteoblasts and bone-resorbing osteoclasts. To investigate its function in osteocytes, the cell type constituting the majority of bone cells, we generated osteocyte-specific beta-catenin-deficient mice (Ctnnb1(loxP/loxP); Dmp1-Cre). Homozygous mutants were born at normal Mendelian frequency with no obvious morphological abnormalities or detectable differences in size or body weight, but bone mass accrual was strongly impaired due to early-onset, progressive bone loss in the appendicular and axial skeleton with mild growth retardation and premature lethality..View full abstract
Awarded by NIH NIAMS
Awarded by NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
This study was partially supported by the Novartis Institutes for BioMedical Research Education Office Postdoctoral Fellowship Program (I. K.) and by NIH NIAMS PO1 AR046798 (L. F. B. and J.Q.F.).