Journal article

Neurotoxic effects of the HCV core protein are mediated by sustained activation of ERK via TLR2 signaling

Amy D Paulino, Kiren Ubhi, Edward Rockenstein, Anthony Adame, Leslie Crews, Scott Letendre, Ronald Ellis, Ian P Everall, Igor Grant, Eliezer Masliah

Journal of NeuroVirology | SPRINGER | Published : 2011

DOI: 10.1007/s13365-011-0039-0

University of Melbourne Researchers

Grants

Awarded by NIH

Awarded by NIDA

Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH

Awarded by NATIONAL INSTITUTE ON DRUG ABUSE

Funding Acknowledgements

We would like to thank Drs. D. Smith and D. Wyles for their discussions and comments. This study is supported by NIH grants MH059745, MH62512, MH62962, and NIDA DA12065.

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Keywords

Cerebrospinal-Fluid
Brain
Male
Neurons
Viral Core Proteins
Coinfection
Interleukin-1 Receptor-Associated Kinases
Mice
Erk
Gene Silencing
Toll-Like Receptor 2
Hiv
Immunohistochemistry
Stat3 Transcription Factor
Neurosciences
Hepacivirus
Life Sciences & Biomedicine
Science & Technology
Humans
Female
Hiv Infections
Animals
Hippocampus
Macrophage Activation
Central-Nervous-System
Hcv
Hepatitis-C-Virus
Neurosciences & Neurology
Middle Aged
Toll-Like Receptors
Hepatitis C
Injections
Map Kinase Signaling System
Entry
Blotting, Western
Map Kinase Kinase Kinases
Tlr2
Virology
Neurodegeneration
Rna, Small Interfering
Real-Time Polymerase Chain Reaction
Infection
Cell-Proliferation
Adult