Bone mineral density is cross sectionally associated with cartilage volume in healthy, asymptomatic adult females: Geelong Osteoporosis Study

SL Brennan; JA Pasco; Flavia M Cicuttini; MJ Henry; MA Kotowicz; GC Nicholson; Anita Wluka

Journal article

Bone mineral density is cross sectionally associated with cartilage volume in healthy, asymptomatic adult females: Geelong Osteoporosis Study

SL Brennan, JA Pasco, Flavia M Cicuttini, MJ Henry, MA Kotowicz, GC Nicholson, Anita Wluka

BONE | ELSEVIER SCIENCE INC | Published : 2011

DOI: 10.1016/j.bone.2011.06.015

Abstract

INTRODUCTION: The association between osteoporosis and osteoarthritis (OA) is controversial. Although previous studies have shown total body, lower limb, spinal and knee BMD and knee cartilage volume to be positively associated, the relationship between other distant site-specific measures of BMD and other knee structures is unknown. The aim of this study was to determine the associations between BMD at eight skeletal sites, and knee structure in asymptomatic young to middle-aged females without any clinical signs of OA. METHODS: One hundred and sixty healthy, asymptomatic females (29-50 yr) underwent magnetic resonance imaging of the knee. BMD was measured at the spine, hip, total body and ..

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University of Melbourne Researchers

Mark Kotowicz Author

Julie Pasco Author

Sharon Brennan-Olsen Author

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by NHMRC

Funding Acknowledgements

This study was funded by the National Health and Medical Research Council (NHMRC) of Australia (251638, 436665), the Victorian Health Promotion Foundation, LEW Carty Foundation and Arthritis Australia. SL Brennan was supported by NHMRC PhD Scholarship (519404, 2010) and NHMRC Early Career Fellowship (1012472, 2011). AE Wluka is the recipient of NHMRC Clinical Career Development Award (545876). We thank the participants who made this study possible and the MRI technicians at Barwon Medical Imaging, Barwon Health, for imaging our participants.