Journal article
Morphometric analysis of subcortical structures in progressive supranuclear palsy: In vivo evidence of neostriatal and mesencephalic atrophy
JCL Looi, MD Macfarlane, M Walterfang, M Styner, D Velakoulis, J Lätt, D van Westen, C Nilsson
Psychiatry Research Neuroimaging | Published : 2011
Abstract
Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by gait and postural disturbance, gaze palsy, apathy, decreased verbal fluency and dysexecutive symptoms, with some of these clinical features potentially having origins in degeneration of frontostriatal circuits and the mesencephalon. This hypothesis was investigated by manual segmentation of the caudate and putamen on MRI scans, using previously published protocols, in 15 subjects with PSP and 15 healthy age-matched controls. Midbrain atrophy was assessed by measurement of mid-sagittal area of the midbrain and pons. Shape analysis of the caudate and putamen was performed using spherical harmonics (SPHARM-PDM,..
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Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development
Funding Acknowledgements
J.C.L. Looi self-funded travel expenses to develop this study with collaborators at Lund University and Skane University Hospital, Lund, Sweden, with support from Lund University for accommodation expenses. M. Styner acknowledges the National Alliance for Medical Image Computing (NA-MIC) NIH U54 EB005149. This study was funded through grants from the Swedish Parkinson Fund and the Swedish Science Council (through the Basal Ganglia Disease Linnaeus Consortium). Christopher Adamson provided scripts to assist with display of shape analysis results.