On the role of differential adhesion in gangliogenesis in the enteric nervous system
Emily J Hackett-Jones, Kerry A Landman, Donald F Newgreen, Dongcheng Zhang
JOURNAL OF THEORETICAL BIOLOGY | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2011
A defining characteristic of the normal development of the enteric nervous system (ENS) is the existence of mesoscale patterned entities called ganglia. Ganglia are clusters of neurons with associated enteric neural crest (ENC) cells, which form in the simultaneously growing gut wall. At first the precursor ENC cells proliferate and gradually differentiate to produce the enteric neurons; these neurons form clusters with ENC scattered around and later lying on the periphery of neuronal clusters. By immunolabelling neural cell-cell adhesion molecules, we infer that the adhesive capacity of neurons is greater than that of ENC cells. Using a discrete mathematical model, we test the hypothesis th..View full abstract
This work was supported by Australian Research Council and National Health and Medical Research Council grants. KAL is an ARC Professorial Fellow. We also wish to extend thanks to Dr. Craig Smith, MCRI and Dr. Vanda Lennon, Mayo Clinic for individual antibodies, and to the Developmental Studies Hybridoma Bank for making many antibodies available.