Journal article

Modelling intrinsic electrophysiological properties of ON and OFF retinal ganglion cells

Tatiana Kameneva, Hamish Meffin, Anthony N Burkitt

Journal of Computational Neuroscience | SPRINGER | Published : 2011

Abstract

ON and OFF retinal ganglion cells (RGCs) display differences in their intrinsic electrophysiology: OFF cells maintain spontaneous activity in the absence of any input, exhibit subthreshold membrane potential oscillations, rebound excitation and burst firing; ON cells require excitatory input to drive their activity and display none of the aforementioned phenomena. The goal of this study was to identify and characterize ionic currents that explain these intrinsic electrophysiological differences between ON and OFF RGCs. A mathematical model of the electrophysiological properties of ON and OFF RGCs was constructed and validated using published patch-clamp data from isolated intact mouse retina..

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Grants

Funding Acknowledgements

The authors wish to thank David Grayden for stimulating discussions that were of invaluable help in carrying out this work and Michael Eager for his help with NEURON software. This research was supported by the Australian Research Council (ARC) through its Special Research Initiative (SRI) in Bionic Vision Science and Technology grant to Bionic Vision Australia (BVA). The Bionic Ear Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program.