SmpB: a novel outer membrane protein present in some Brachyspira hyodysenteriae strains.
James Holden, George Moutafis, Taghrid Istivan, Peter J Coloe, Peter M Smooker
Vet Microbiol | Elsevier BV | Published : 2006
A novel outer membrane protein-encoding gene was identified in Brachyspira hyodysenteriae. The predicted protein, SmpB, was encoded by a gene that contains regions of identity with that encoding the previously identified lipoprotein SmpA. However, the majority of the reading frame encoding SmpA and SmpB share no detectable similarity. Analysis of several strains revealed that B. hyodysenteriae harbours either smpA or the newly identified gene smpB, but not both. smpB encodes for a slightly larger protein than smpA, 17.6 and 16.8 kDa, respectively. The predicted proteins share an identical leader sequence and the first 10 amino acids of the mature protein, however, the remainder of the predic..View full abstract