Journal article
Distribution of human papillomavirus genotypes in archival cervical tissue from women with cervical cancer in urban Sri Lanka
NA Samarawickrema, SN Tabrizi, J Hewavisenthi, T Leong, SM Garland
International Journal of Gynecology and Obstetrics | WILEY | Published : 2011
Abstract
Objective: To identify the contributions of various human papillomavirus (HPV) genotypes in tissue samples from women diagnosed with cervical cancer in Sri Lanka. Methods: In a retrospective study, archival cervical tissues samples (n = 108) obtained from Sri Lankan women diagnosed with histologically proven invasive squamous cell carcinoma between 2006 and 2007 were tested for HPV. Genotyping of HPV DNA was performed using an INNO-LiPA assay. Results: Overall, 93% of tumor samples tested positive for HPV DNA. HPV types 16 and 18 accounted collectively for 83.4% of the positive samples. Conclusion: The findings suggest that the HPV genotypes responsible for causing cervical cancer in Sri Lan..
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Funding Acknowledgements
S.M.G. has received advisory board fees and grant support from CSL and GlaxoSmithKline (GSK); lecture fees from Merck, GSK, and Sanofi Pasteur; funding from her institution to conduct HPV vaccine studies for Merck, Sharp and Dohme, and GSK; and is a member of the Merck Global Advisory Board and the Merck Scientific Advisory Committee for HPV. The other authors have no conflicts of interest.