Homeobox gene Distal-less 3 (DLX3) is a regulator of villous cytotrophoblast differentiation
A Chui, DA Evseenko, SP Brennecke, JA Keelan, B Kalionis, P Murthi
PLACENTA | W B SAUNDERS CO LTD | Published : 2011
Dlx3, a member of the large homeobox gene family of transcription factors, is important for murine placental development. Targeted deletion of Dlx3 in the mouse results in embryonic death due to placental failure. This study investigated the role of human DLX3 in villous cytotrophoblast (VCT) differentiation in the placenta. Primary VCT from human term placentae, which spontaneously differentiate when maintained in culture over 72 h, showed a significant increase in mRNA and protein expression of DLX3 and 3βHSD. The functional role of DLX3 was determined using trophoblast derived-cell line, BeWo. Forskolin treated BeWo cells showed significantly increased DLX3 mRNA and protein expression. Fo..View full abstract
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Awarded by Australian National Health and Medical Research Council (NHMRC)
This work was supported by an Australian National Health and Medical Research Council (NHMRC) project grant (#509140) to Dr. P. Murthi and by Royal Women's Hospital postgraduate scholarship support, the Arthur Nylasy Award and the Felix Meyer Postgraduate Scholarship, both from The University of Melbourne, to A.Chui. JA Keelan is supported by the Women and Infants Research Foundation (WIRF) of Western Australia.