The Alzheimer's therapeutic PBT2 promotes amyloid-beta degradation and GSK3 phosphorylation via a metal chaperone activity

Peter J Crouch; Maria S Savva; Lin W Hung; Paul S Donnelly; Alexandra I Mot; Sarah J Parker; Mark A Greenough; Irene Volitakis; Paul A Adlard; Robert A Cherny; Colin L Masters; Ashley I Bush; Kevin J Barnham; Anthony R White

Journal article

The Alzheimer's therapeutic PBT2 promotes amyloid-beta degradation and GSK3 phosphorylation via a metal chaperone activity

Peter J Crouch, Maria S Savva, Lin W Hung, Paul S Donnelly, Alexandra I Mot, Sarah J Parker, Mark A Greenough, Irene Volitakis, Paul A Adlard, Robert A Cherny, Colin L Masters, Ashley I Bush, Kevin J Barnham, Anthony R White

Journal of Neurochemistry | WILEY | Published : 2011

DOI: 10.1111/j.1471-4159.2011.07402.x

University of Melbourne Researchers

Kevin Barnham Author Florey Department of Neuroscience and Mental Health

Ashley Bush Author Florey Department of Neuroscience and Mental Health

Colin Masters Author Florey Department of Neuroscience and Mental Health

Peter Crouch Author Biochemistry and Pharmacology

Paul Adlard Author Florey Department of Neuroscience and Mental Health

Related Projects (1)

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Grants

Awarded by Australian National Health and Medical Research Council

Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council (Program Grant No. 400202). AIB is an Australian Research Council Federation Fellow. KJB is a National Health and Medical Research Council Senior Research Fellow.