Acute exposure to prion infection induces transient oxidative stress progressing to be cumulatively deleterious with chronic propagation in vitro

Cathryn L Haigh; Amelia R McGlade; Victoria Lewis; Colin L Masters; Victoria A Lawson; Steven J Collins

Journal article

Acute exposure to prion infection induces transient oxidative stress progressing to be cumulatively deleterious with chronic propagation in vitro

Cathryn L Haigh, Amelia R McGlade, Victoria Lewis, Colin L Masters, Victoria A Lawson, Steven J Collins

Free Radical Biology and Medicine | ELSEVIER SCIENCE INC | Published : 2011

DOI: 10.1016/j.freeradbiomed.2011.03.035

University of Melbourne Researchers

Steven Collins Author Medicine - Royal Melbourne Hospital

Colin Masters Author Florey Department of Neuroscience and Mental Health

Vicki Lawson Author Microbiology and Immunology

Vicki Lewis Author Medicine - Royal Melbourne Hospital

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Funding Acknowledgements

The authors would like to acknowledge A/Prof AF Hill for the kind gift of the pIRES vector containing the PrP open reading frames and Dr Simon Drew for the SR-VAD-FMK reagent. The OBL-21 cell line used in this study were a kind gift of Dr Michael Oldstone, The Scripps Research Institute, La Jolla, California, USA. This study was funded by a Brain Foundation research grant. SJC is supported by an NH&MRC Practitioner Fellowship #400183 and an NH&MRC programme grant #400202. VL is supported by an NH&MRC Training (Postdoctoral) Fellowship #567123. VAL is supported by a University of Melbourne CR Roper fellowship.