Journal article

Hemostatic Response in Paediatric Patients Undergoing Cardiopulmonary Bypass Surgery

Vera Ignjatovic, Jenny Than, Robyn Summerhayes, Fiona Newall, Stephen Horton, Andrew Cochrane, Paul Monagle



This prospective, single-center cohort study aimed to evaluate the hemostatic response during and after Cardiopulmonary Bypass (CPB) surgery in a large cohort of children up to 6 years of age. Blood samples were drawn at eight time points: post-induction of anesthesia, pre-unfractionated heparin (UFH), post-UFH, post-initiation of bypass, pre-protamine, post-protamine, post-chest-closure, and 6 h post-chest-closure. As expected, all measures of the UFH effect increased significantly post-UFH bolus and decreased post-protamine administration. However, thrombin generation remained inhibited compared to baseline values despite the post-UFH reversal by protamine. We also demonstrate that residua..

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