Hemostatic Response in Paediatric Patients Undergoing Cardiopulmonary Bypass Surgery
Vera Ignjatovic, Jenny Than, Robyn Summerhayes, Fiona Newall, Stephen Horton, Andrew Cochrane, Paul Monagle
PEDIATRIC CARDIOLOGY | SPRINGER | Published : 2011
This prospective, single-center cohort study aimed to evaluate the hemostatic response during and after Cardiopulmonary Bypass (CPB) surgery in a large cohort of children up to 6 years of age. Blood samples were drawn at eight time points: post-induction of anesthesia, pre-unfractionated heparin (UFH), post-UFH, post-initiation of bypass, pre-protamine, post-protamine, post-chest-closure, and 6 h post-chest-closure. As expected, all measures of the UFH effect increased significantly post-UFH bolus and decreased post-protamine administration. However, thrombin generation remained inhibited compared to baseline values despite the post-UFH reversal by protamine. We also demonstrate that residua..View full abstract
The authors acknowledge the assistance of the cardio-thoracic surgical unit and, in particular, Dr. Martin Bennett. The authors are also very grateful for the assistance of the PICU nursing staff in collecting the S8 samples. The Haematology Research Group provided internal funding.