Journal article

Differences between the pre-menopausal and post-menopausal uterine fibroid vasculature

GC Weston, F Cattrall, F Lederman, BJ Vollenhoven, PAW Rogers

MATURITAS | ELSEVIER IRELAND LTD | Published : 2005

Abstract

OBJECTIVES: To quantitatively examine differences in microvascular density between fibroid and myometrial tissue from fibroid uteri removed at hysterectomy, both before and after the menopause, and with hormone replacement therapy. METHODS: Factor VIII immunostaining of formalin fixed tissues was used to identify blood vessels, and the vessels counted by an investigator blinded to tissue type or menopausal status. RESULTS: The mean myometrial: fibroid MVD ratio was 2.38 higher in the post-menopausal group (95% CI: 0.12, 4.65, p=0.0474) than in the pre-menopausal group, with the hormone therapy (HT)-using post-menopausal group lying in between. An increase in microvascular density in the myom..

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