Journal article

Identification of Plant-like Galactolipids in Chromera velia, a Photosynthetic Relative of Malaria Parasites

Cyrille Y Botte, Yoshiki Yamaryo-Botte, Jan Janouskovec, Thusita Rupasinghe, Patrick J Keeling, Paul Crellin, Ross L Coppel, Eric Marechal, Malcolm J McConville, Geoffrey I McFadden

Journal of Biological Chemistry | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2011

Abstract

Apicomplexa are protist parasites that include Plasmodium spp., the causative agents of malaria, and Toxoplasma gondii, responsible for toxoplasmosis. Most Apicomplexa possess a relict plastid, the apicoplast, which was acquired by secondary endosymbiosis of a red alga. Despite being nonphotosynthetic, the apicoplast is otherwise metabolically similar to algal and plant plastids and is essential for parasite survival. Previous studies of Toxoplasma gondii identified membrane lipids with some structural features of plastid galactolipids, the major plastid lipid class. However, direct evidence for the plant-like enzymes responsible for galactolipid synthesis in Apicomplexan parasites has not b..

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Grants

Funding Acknowledgements

This work was supported in part by European Research Council FP7 Marie Curie Actions via an International Outgoing Fellowship Marie Curie fellowship (to C. Y. B.), National Health and Medical Research Council of Australia, CNRS, and Agence Nationale de la Recherche ReGal grant (to E. M.).