Journal article

Clinical isolated syndrome: A 3-year follow-up study in China

Yaou Liu, Yunyun Duan, Chunshui Yu, Wen Qin, Hai Chen, Huiqing Dong, Jing Ye, Helmut Butzkueven, Kuncheng Li

Clinical Neurology and Neurosurgery | ELSEVIER | Published : 2011


OBJECTIVE: To summarize the characteristics of Chinese clinically isolated syndrome (CIS) patients and their 3-year follow-up results. Investigate the relationship between CIS features and clinical outcomes. METHODS: Forty-nine CIS patients were recruited and 42 of them were able to be followed up for a mean of 38 months (range 26-48 months). We recorded baseline features including patient demographics, site of CIS, presence or absence of cerebrospinal fluid (CSF) oligoclonal bands (OCB) and MRI lesions in brain and spinal cord. The incidence of conversion to clinically definite MS (CDMS) or neuromyelitis optica (NMO) after CIS was calculated, and the relationship between baseline features a..

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