The Transcriptome of Trichuris suis - First Molecular Insights into a Parasite with Curative Properties for Key Immune Diseases of Humans
Cinzia Cantacessi, Neil D Young, Peter Nejsum, Aaron R Jex, Bronwyn E Campbell, Ross S Hall, Stig M Thamsborg, Jean-Pierre Scheerlinck, Robin B Gasser
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2011
BACKGROUND: Iatrogenic infection of humans with Trichuris suis (a parasitic nematode of swine) is being evaluated or promoted as a biological, curative treatment of immune diseases, such as inflammatory bowel disease (IBD) and ulcerative colitis, in humans. Although it is understood that short-term T. suis infection in people with such diseases usually induces a modified Th2-immune response, nothing is known about the molecules in the parasite that induce this response. METHODOLOGY/PRINCIPAL FINDINGS: As a first step toward filling the gaps in our knowledge of the molecular biology of T. suis, we characterised the transcriptome of the adult stage of this nematode employing next-generation se..View full abstract
This research was supported largely by the Australian Research Council (RBG). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Support from the Victorian Life Sciences Computation Initiative (VLSCI) and IBM Collaboratory is gratefully acknowledged (RBG). The data reported here are available upon request (http://research.vet.unimelb.edu.au/gasserlab/contact.html).