Journal article
Association of ACE2 genetic variants with blood pressure, left ventricular mass, and cardiac function in caucasians with type 2 diabetes
SK Patel, B Wai, M Ord, RJ MacIsaac, S Grant, E Velkoska, S Panagiotopoulos, G Jerums, PM Srivastava, LM Burrell
American Journal of Hypertension | Published : 2012
DOI: 10.1038/ajh.2011.188
Abstract
Background Cardiovascular disease is common in diabetes, and is associated with activation of the renin-angiotensin system (RAS). Angiotensin-converting enzyme (ACE)2 is a recently described member of the RAS, and this study investigated whether ACE2 polymorphisms are associated with hypertension, left ventricular (LV) mass, and cardiac function in type 2 diabetes. Methods Variants in ACE2 (rs1978124, rs2074192, rs4240157, rs4646156, rs4646188) were examined in 503 Caucasian subjects with type 2 diabetes. As ACE2 is located on the X chromosome, analyses were performed separately for men and women. Hypertension was defined by a history of hypertension, and/or antihypertensive medications or b..
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Funding Acknowledgements
This study was undertaken with the generous support of the National Health and Medical Research Council (NHMRC), Australia. S.K.P. was supported by an Early Career Researcher Grant, University of Melbourne, B.W. was supported by an NHMRC and National Heart Foundation scholarship award and Pfizer CardioVascular Lipid grant. We thank the sonographers who performed the echocardiograms and the individuals who participated in this study. S.K.P. designed the study, performed the laboratory work, analyzed and interpreted the data, wrote the manuscript, and reviewed and edited the manuscript. B.W. acquired, analyzed, and interpreted the data, and reviewed and edited the manuscript. M.O., R.J.M, S.G., E.V., S.P., and G.J. acquired the data and reviewed and edited the manuscript. P.M.S. acquired, analyzed, and reviewed the manuscript. L.M.B. designed the study, interpreted the data, wrote the manuscript and reviewed and edited the manuscript.