Human papillomavirus prevalence among indigenous and non-indigenous Australian women prior to a national HPV vaccination program
Suzanne M Garland, Julia ML Brotherton, John R Condon, Peter B McIntyre, Matthew P Stevens, David W Smith, Sepehr N Tabrizi
BMC Medicine | BMC | Published : 2011
BACKGROUND: Indigenous women in Australia have a disproportionate burden of cervical cancer despite a national cervical screening program. Prior to introduction of a national human papilloma virus (HPV) vaccination program, we determined HPV genotype prevalence by Indigenous status and residence in remote areas. METHODS: We recruited women aged 17 to 40 years presenting to community-based primary health services for routine Pap screening across Australia. A liquid-based cytology (LBC) cervical specimen was tested for HPV DNA using the AMPLICOR HPV-DNA test and a PGMY09/11-based HPV consensus PCR; positive specimens were typed by reverse hybridization. We calculated age-adjusted prevalence by..View full abstract
Funding was received from the Cooperative Research Centre for Aboriginal Health (CRCAH) for the pilot study in Alice Springs, Northern Territory. Grants in Aid from GlaxoSmithKline and CSL Ltd, Melbourne, Australia supported the main study. Project design, analysis and write up of the study findings was the work of the chief investigators, with no input from those supporting the funding for the study.Other than the grant funding received for this study (see below), JC, ST, MS and DS have no competing interests. JB and PM were co-authors on an investigator-driven HPV serosurveillance study in which laboratory testing was funded by CSL Limited. JB and SG are partner investigators on an Australian Research Council linkage grant in which CSL is a partner investigator. SG has received advisory board fees and grant support from CSL and GlaxoSmithKline, and lecture and consultancy fees from Merck and Co. SG reports having previously owned stock in CSL. SG has received grant support through her institution from Merck and Co and GlaxoSmithKline (GSK) to carry out clinical trials for HPV/cervical cancer vaccines, and she is a member of the Merck global advisory and scientific advisory boards.