The β 3-adrenergic agonist (BRL35135A) acutely increases oxygen consumption and plasma intermediate metabolites in sheep

Abstract

There is evidence that an atypical adrenoreceptor subtype is involved in mediating some of the physiological effects of catecholamines, particularly in some adipose tissue sites. Therefore, three experiments were conducted to determine the metabolic and energetic responses to oral administration of the purported β 3-agonist BRL35135A in ruminant lambs. The post-prandial increase in O 2 consumption (0.109 versus 0.139 L/min) and CO 2 production (0.102 versus 0.127 L/min) at 30 min after feeding was greater (P < 0.05) in the lambs receiving 5 mg of the BRL35135A. Treatment • time interactions over the period between -50 and 220 min indicate significant increases in plasma non-esterified fatty ..