Overview and recent advances in neuropathology: Part 2: Neurodegeneration

Abstract

The sections in the following review cover six main neurodegenerative diseases. The first article on Alzheimer's disease (AD) outlines themajor evidence available to date that linksAβamyloidpeptide as aproximal cause of AD. The article also highlights how an initial finding of theprotein content of the amyloidplaque seen in the brains ofpatients with ADhas led to many very significant findings in the neuroscience field. The next section outlines the many and recent advances that have occurred in the field of frontotemporal lobar degeneration (FTLD), including the most recent finding related to the fused sarcoma gene (FUS) and the newest nomenclature whereby the FTLD is subtyped according to ..