Journal article

Overview and recent advances in neuropathology. Part 2: Neurodegeneration

Colin L Masters, Jillian J Kril, Glenda M Halliday, Roger Pamphlett, Steven Collins, Andrew F Hill, Catriona McLean

Pathology | ELSEVIER | Published : 2011


The sections in the following review cover six main neurodegenerative diseases. The first article on Alzheimer's disease (AD) outlines the major evidence available to date that links Aβ-amyloid peptide as a proximal cause of AD. The article also highlights how an initial finding of the protein content of the amyloid plaque seen in the brains of patients with AD has led to many very significant findings in the neuroscience field. The next section outlines the many and recent advances that have occurred in the field of frontotemporal lobar degeneration (FTLD), including the most recent finding related to the fused sarcoma gene (FUS) and the newest nomenclature whereby the FTLD is subtyped acco..

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