Journal article
House dust mite sensitization in toddlers predicts current wheeze at age 12 years
CJ Lodge, AJ Lowe, LC Gurrin, DJ Hill, CS Hosking, RU Khalafzai, JL Hopper, MC Matheson, MJ Abramson, KJ Allen, SC Dharmage
Journal of Allergy and Clinical Immunology | Published : 2011
Abstract
Background: Identification of children at risk of developing asthma provides a window of opportunity for risk-reducing interventions. Allergen sensitization might identify high-risk children. Objective: We sought to determine whether skin prick tests (SPTs) to individual allergens up to age 2 years predict wheeze at age 12 years. Methods: In a birth cohort of 620 children oversampled for familial allergy, sensitization was assessed by using SPTs (monosensitized, polysensitized, or either) to 6 allergens at ages 6, 12, and 24 months. Wheeze and eczema were recorded 18 times during the first 2 years. Current wheeze was recorded at age 12 years. Adjusted associations were evaluated by multiple ..
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Funding Acknowledgements
Initial support for the study was from Nestle Australia, and the 12-year follow-up was supported by the Asthma Foundation of Victoria. C.J.L. is supported by the Sidney Myer Health Fund and the National Health and Medical Research Council of Australia (NHMRC). A.J.L., L. C. G., J.L.H., M. C. M., and S. C. D. are supported by the NHMRC. K.J.A. is supported by the Charles and Sylvia Viertel Charitable Foundation.M. J. Abramson was part of the Landmark Symposium for GlaxoSmithKline and receives research support from Reckitts Benckiser. D. Hill has received past support from Nutricia, SHS International, and Nestle for research, and has presented lectures at sponsored meetings. The rest of the authors have declared that they have no conflict of interest.