Journal article
No clear potentiation of antidepressant medication effects by folic acid vitamin B12 in a large community sample
H Christensen, A Aiken, PJ Batterham, J Walker, AJ MacKinnon, M Fenech, IB Hickie
Journal of Affective Disorders | Published : 2011
Abstract
Background: Observational studies link low folate levels to depressive symptoms and to poor antidepressant medication response. Evidence supports a role for folate in potentiating the effect of antidepressant medications. Aim: This prospective study examines the effects of folic acid + vitamin B12 supplementation and antidepressant medication in a community-based study of older adults with depressive symptoms. Method: A randomised controlled trial investigated the effectiveness of a medicinal and two behavioural preventive interventions over a two year period. The medicinal intervention compared dietary supplementation of 400 mcg/d folic acid + 100 mcg/d vitamin B12 to placebo. Self reported..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study was supported by beyondblue: The National Depression Initiative and the Australian Government Department of Health and Ageing. HC is supported by NHMRC Fellowship 525411. PB and JW are supported by NHMRC Capacity Building Grant 418020. The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.