Journal article

Subclinical psychosis and depression: Co-occurring phenomena that do not predict each other over time

JTW Wigman, A Lin, WAM Vollebergh, J van Os, QAW Raaijmakers, B Nelson, G Baksheev, AR Yung



BACKGROUND: The path from subclinical psychotic experiences to clinical disorder is thought to be mediated by the persistence of subclinical psychotic experiences. One of the factors that is likely associated with this persistence is depression. Although commonly viewed as interrelated concepts, the exact relationship between subclinical psychosis and depression is not clear. METHODS: Cross-lagged path modeling was used to explore the relationship between subclinical psychosis and depression across and over time in an adolescent population seeking assistance for non-psychotic disorders (N=138), measured at four occasions over a two-year period. RESULTS: Subclinical psychosis and depression w..

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Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

The current collaboration was sponsored by a grant to Johanna Wigman from the Dutch "Stichting Koningsheide". Ashleigh Lin is supported by a National Health and Medical Research Council (NHMRC) program grant (566529). Alison Yung is supported by a NHMRC Senior Research Fellowship and a NHMRC program grant (566529). Barnaby Nelson is supported by a NARSAD Young Investigator Award and a Ronald Phillip Griffith Fellowship. This research project was supported by the Colonial Foundation. These funding sources had no further role in study design; in the collection, analysis and interpretation of data: in the writing of the report; and in the decision to submit the paper for publication.Dr. van Os is/has been an unrestricted research grant holder with, or has received financial compensation as an independent symposium speaker from Eli Lilly, BMS, Lundbeck, Organon, Janssen-Cilag, GSK, AstraZeneca, Pfizer and Servier, companies that have an interest in the treatment of psychosis. All other authors have no conflict of interests.