Journal article
Association of interleukin 23 receptor gene with sarcoidosis
HS Kim, D Choi, LL Lim, G Allada, JR Smith, CR Austin, TM Doyle, KA Goodwin, JT Rosenbaum, TM Martin
Disease Markers | HINDAWI LTD | Published : 2011
Open access
Abstract
Interleukin 23 receptor (IL23R) gene has been reported as a genetic factor strongly associated with inflammatory bowel disease, psoriasis, and ankylosing spondylitis. We investigated the association between IL23R gene single nucleotide polymorphisms (SNPs) and susceptibility to sarcoidosis, including the clinical manifestation of uveitis. Ninety-one sarcoidosis subjects (58 with and 33 without uveitis) and 104 healthy controls were genotyped for eleven IL23R SNPs. DNA was amplified using specific PCR primers and genotyped by denaturing HPLC and/or direct DNA sequencing. Case-control frequency comparisons were analyzed using Chi square test. Three IL23R SNPs, rs7517847 (intron 6), rs11465804 ..
View full abstractGrants
Awarded by National Institutes of Health (NIH; Bethesda, MD, USA)
Funding Acknowledgements
This work was supported by R01 EY013139 and EY0105712 from the National Institutes of Health (NIH; Bethesda, MD, USA); and by Research to Prevent Blindness (New York, NY, USA) awards to the Casey Eye Institute, JRS, JTR, and TMM.