In Pursuit of Individualised Margins for Prostate Cancer Patients Undergoing Image-guided Radiotherapy: The Effect of Body Mass Index on Intrafraction Prostate Motion

Abstract

Aims: To analyse the relationship between body mass index (BMI) and intrafraction displacement in patients undergoing prostate cancer image-guided radiotherapy. Materials and methods: An analysis was carried out on 151 prostate cancer patients treated with radical dose radiotherapy between January 2007 and March 2009. Patients had their height, weight and daily intrafraction prostate displacement data collected prospectively during fiducial marker image-guided radiotherapy with orthogonal imaging. For each of anterior-posterior, left-right and superior-inferior axes, a univariable linear regression analysis was carried out with the individual patient standard deviation of shift as the respon..