Journal article

The TGF-beta superfamily cytokine, MIC-1/GDF15: A pleotrophic cytokine with roles in inflammation, cancer and metabolism

Samuel N Breit, Heiko Johnen, Andrew D Cook, Vicky WW Tsai, Mohammad G Mohammad, Tamara Kuffner, Hong Ping Zhang, Christopher P Marquis, Lele Jiang, Glen Lockwood, Michelle Lee-Ng, Yasmin Husaini, Liyun Wu, John A Hamilton, David A Brown

Growth Factors | TAYLOR & FRANCIS LTD | Published : 2011


Macrophage inhibitory cytokine-1 (MIC-1/GDF15) is associated with cardiovascular disease, inflammation, body weight regulation and cancer. Its serum levels facilitate the diagnosis and prognosis of cancer and vascular disease. Furthermore, its serum levels are a powerful predictor of all-cause mortality, suggesting a fundamental role in biological processes associated with ageing. In cancer, the data available suggest that MIC-1/GDF15 is antitumorigenic, but this may not always be the case as disease progresses. Cancer promoting effects of MIC-1/GDF15 may be due, in part, to effects on antitumour immunity. This is suggested by the anti-inflammatory and immunosuppressive properties of MIC-1/G..

View full abstract


Funding Acknowledgements

This research was supported in part by grants from The National Health and Medical Research Council of Australia, a New South Wales Health Research and Development Infrastructure grant and St Vincent's Clinic Foundation grant. David A. Brown is supported by an NHMRC Career Development Fellowship. David A. Brown and Samuel N. Breit are co-inventors on patents filed by St Vincent's Hospital, which pertain to the use of a serum-based assay for use in the fields of cancer and inflammatory disease. Other authors declare no conflict of interest.