AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer

Joanna C Chan; Katherine M Hannan; Kim Riddell; Yee Ng Pui; Abigail Peck; Rachel S Lee; Sandy Hung; Megan V Astle; Megan Bywater; Meaghan Wall; Gretchen Poortinga; Katarzyna Jastrzebski; Karen E Sheppard; Brian A Hemmings; Michael N Hall; Ricky W Johnstone; Grant A McArthur; Ross D Hannan; Richard B Pearson

Journal article

AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer

Joanna C Chan, Katherine M Hannan, Kim Riddell, Yee Ng Pui, Abigail Peck, Rachel S Lee, Sandy Hung, Megan V Astle, Megan Bywater, Meaghan Wall, Gretchen Poortinga, Katarzyna Jastrzebski, Karen E Sheppard, Brian A Hemmings, Michael N Hall, Ricky W Johnstone, Grant A McArthur, Ross D Hannan, Richard B Pearson

Science Signaling | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2011

DOI: 10.1126/scisignal.2001754

University of Melbourne Researchers

Grant McArthur Author Melbourne Medical School

Richard Pearson Author The Sir Peter MacCallum Department of Oncology

Ricky Johnstone Author The Sir Peter MacCallum Department of Oncology

Sandy Hung Author Ophthalmology Eye and Ear Hospital

Katherine Hannan Author Biochemistry and Pharmacology

Related Projects (4)

Research Fellowship

nan

AKT regulation of growth and proliferation

Ribosome synthesis and function is critical for normal cell growth and division and hence this process is exquisitely regulated. Conversely,..

Regulation of ribosomal gene transcription by c-MYC during differentiation and lymphomagenesis.

A fundamental question in medical biology revolves around how cells respond to the demands to grow and produce proteins, particularly in the..

"Deregulation of ribosome signalling, synthesis and function during malignant transformation."

A major feature of tumour progression is accelerated cell growth and protein synthesis. Moreover, increased synthesis of ribosomes (the prot..

Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Funding Acknowledgements

This work was supported by grants and fellowships from the National Health and Medical Research Council (NHMRC) of Australia to R. D. H. (NHMRC #166908, #400120, and #509088) and to R. B. P. (NHMRC # 509087 and # 400116), Cancer Council Victoria to R. B. P., and Swiss National Science Foundation to M.N.H. R.W.J. is an NHMRC Principal Research Fellow. M. W. is funded by a Clinical Research Fellowship from the Victorian Cancer Agency. This work is supported by NHMRC program and project grants plus grants from the Victorian Cancer Agency and Australian Rotary Health.