Journal article
Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice
AP Ng, SJ Loughran, D Metcalf, CD Hyland, CA De Graaf, Y Hu, GK Smyth, DJ Hilton, BT Kile, WS Alexander
Blood | AMER SOC HEMATOLOGY | Published : 2011
Abstract
Hematopoietic stem cells (HSCs) are rare residents of the bone marrow responsible for the lifelong production of blood cells. Regulation of the balance between HSC self-renewal and differentiation is central to hematopoiesis, allowing precisely regulated generation of mature blood cells at steady state and expanded production at times of rapid need, as well as maintaining ongoing stem cell capacity. Erg, a member of the Ets family of transcription factors, is deregulated in cancers; and although Erg is known to be required for regulation of adult HSCs, its precise role has not been defined. We show here that, although heterozygosity for functional Erg is sufficient for adequate steady-state ..
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Awarded by Australian National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the Australian National Health and Medical Research Council (program grant 461219; project grant 516726; fellowships, W.S.A., B.T.K., A.P.N.; and Independent Research Institutes Infrastructure Support Scheme Grant 361646), the Australian Research Council (fellowship; B.T.K.), the Sylvia and Charles Viertel Charitable Foundation (fellowship; B.T.K.), the Cancer Council, Victoria (Carden Fellowship Fund, D.M.; and Sydney Parker Smith Postdoctoral Research Fellowship, C.A.d.G.), the Australian Department of Education, Science and Training (scholarship; S.J.L., C.A.d.G.), Australian Stem Cell Center (Postgraduate Supplementary Scholarship; C.A.d.G.), Haematology Society of Australia and New Zealand/AMGEN (New Investigator Scholarship; A.P.N.), the Australian Cancer Research Fund, and the Victorian State Government (Operational Infrastructure Support grant).