Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance

Francois-Xavier Hubert; Sarah A Kinkel; Gayle M Davey; Belinda Phipson; Scott N Mueller; Adrian Liston; Anna I Proietto; Ping ZF Cannon; Simon Forehan; Gordon K Smyth; Li Wu; Christopher C Goodnow; Francis R Carbone; Hamish S Scott; William R Heath

Journal article

Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance

Francois-Xavier Hubert, Sarah A Kinkel, Gayle M Davey, Belinda Phipson, Scott N Mueller, Adrian Liston, Anna I Proietto, Ping ZF Cannon, Simon Forehan, Gordon K Smyth, Li Wu, Christopher C Goodnow, Francis R Carbone, Hamish S Scott, William R Heath

Blood | AMER SOC HEMATOLOGY | Published : 2011

DOI: 10.1182/blood-2010-06-286393

University of Melbourne Researchers

Francis Carbone Author Microbiology and Immunology

Scott Mueller Author Microbiology and Immunology

William Heath Author Microbiology and Immunology

Sarah Kinkel Author Medical Biology (W.E.H.I.)

Gayle Davey Author Microbiology and Immunology

Related Projects (2)

NHMRC RESEARCH FELLOWSHIP 2007 - HEATH

I am an cellular immunologist determining the mechanisms by which immunity to foreign organisms is generated, how tolerance to self tissues ..

2007 PROGRAM GRANT - (ANTIGEN PRESENTATION, RECOGNITION AND THE IMMUNE RESPONSE)

The early events in immunity require various molecular interactions. We will examine the structural and biophysical basis for some of these ..

Grants

Awarded by NHMRC

Awarded by EU

Funding Acknowledgements

This work was supported by the NHMRC and fellowships from La Fondation pour la Recherche Medicale (FRM) and the 6th FP of the EU, Marie Curie, contract 040998 (F.-X. H.); by Australian Postgraduate Awards (S.A.K.); NHMRC fellowships (171601, 461202, and 461204); NHMRC program grants (257501, 264573, 406700, and 454465); Eurothymaide and EURAPS; 6th FP of the EU; and the Nossal Leadership Award from WEHI (H.S.S.).