Cortical activation and lamina terminalis functional connectivity during thirst and drinking in humans
MJ Farrell, TK Bowala, M Gavrilescu, PA Phillips, MJ McKinley, RM McAllen, DA Denton, GF Egan
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2011
The pattern of regional brain activation in humans during thirst associated with dehydration, increased blood osmolality, and decreased blood volume is not known. Furthermore, there is little information available about associations between activation in osmoreceptive brain regions such as the organum vasculosum of the lamina terminalis and the brain regions implicated in thirst and its satiation in humans. With the objective of investigating the neuroanatomical correlates of dehydration and activation in the ventral lamina terminalis, this study involved exercise-induced sweating in 15 people and measures of regional cerebral blood flow (rCBF) using a functional magnetic resonance imaging t..View full abstract
This work was supported by the Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation and the G. Harold and Leila Y. Mathers Charitable Foundation. M. J. McKinley and G. F. Egan are National Health and Medical Research Council (Australia) Fellows.