Journal article
Functional expression of IgG-Fc receptors in human airway smooth muscle cells
YXC Xia, M Schuliga, M Shepherd, M Powell, T Harris, SY Langenbach, PS Tan, WT Gerthoffer, PM Hogarth, AG Stewart, GA Mackay
American Journal of Respiratory Cell and Molecular Biology | AMER THORACIC SOC | Published : 2011
Abstract
IgE-Fc receptors and IgG-Fc receptors are expressed on hematopoietic cells, but some evidence suggests that these receptors are also found on nonhematopoietic cells, including human airway smooth muscle(hASM)cells.Ourstudy characterizes the expression of IgE-Fc receptors (FcεRI/CD23) and IgG-Fc receptors (FcγRs-I, -II, and -III) in cultured hASM cells by flow cytometry and Western blotting, and the functional activity of receptors was determined through quantification of cell proliferation and released cytokines. Expression of Fc receptor-linked intracellular signaling proteins and phosphorylation of the mitogen-activated protein kinases (MAPKs) extracellular signal-regulated kinase 1/2 and ..
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Awarded by National Heart, Lung, and Blood Institute
Funding Acknowledgements
[ "This work was supported by funding from the Asthma Foundation of Queensland, Australia (G. A. M.) and the National Health and Medical Research Council, Australia (A. G. S. [grant 509,001] and P.M.H.).", "W.T.G. received a sponsored grant from the National Institutes of Health for more than $100,001 and consultancy fees for $1,001-$5,000; P. M. H. received a patent for Trillium Pharmaceuticals (Canada) for Fc receptor DNA and for SCE drugs (no income received or likely); M. S. received lecture fees from GlaxoSmithKline for up to $1,000. None of the other authors has a financial relationship with a commercial entity that has an interest in the subject of this manuscript." ]