Journal article
Effect of a partially hydrolyzed whey infant formula at weaning on risk of allergic disease in high-risk children: A randomized controlled trial
AJ Lowe, CS Hosking, CM Bennett, KJ Allen, C Axelrad, JB Carlin, MJ Abramson, SC Dharmage, DJ Hill
Journal of Allergy and Clinical Immunology | Published : 2011
Abstract
Background: Partially hydrolyzed whey formula (pHWF) has been recommended for infants with a family history of allergic disease at the cessation of exclusive breast-feeding to promote oral tolerance and prevent allergic diseases. Objective: To determine whether feeding infants pHWF reduces their risk of allergic disease. Methods: A single-blind (participant) randomized controlled trial was conducted to compare allergic outcomes between infants fed a conventional cow's milk formula, a pHWF, or a soy formula. Before birth, 620 infants with a family history of allergic disease were recruited and randomized to receive the allocated formula at cessation of breast-feeding. Skin prick tests to 6 co..
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Funding Acknowledgements
Nestec Ltd, a subsidiary of Nestle Australia, provided the study formula and staff funding for the first 6 years of the study.A. J. Lowe has received research support from Dairy Australia. K. J. Allen has received speaker's honoraria from Wyeth and Nutricia. D. J. Hill has received research support from Nestle Australia, SHS International, and Nutricia. The rest of the authors have declared that they have no conflict of interest.