Journal article
A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk
JM Genkinger, D Spiegelman, KE Anderson, L Bernstein, PA Van Den Brandt, EE Calle, DR English, AR Folsom, JL Freudenheim, CS Fuchs, GG Giles, E Giovannucci, PL Horn-Ross, SC Larsson, M Leitzmann, S Männistö, JR Marshall, AB Miller, AV Patel, TE Rohan Show all
International Journal of Cancer | Published : 2011
DOI: 10.1002/ijc.25794
Abstract
Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while associations for height have been null. Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow-up. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Compared to individuals with a body mass index (BMI) at baseline between 21-22.9 kg/m2, pancreatic cancer risk was 47% higher (95%CI:23-75%) among obese..
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Awarded by National Cancer Institute
Funding Acknowledgements
Grant sponsor: National Institutes of Health; Grant numbers: CA098566 and CA55075