Journal article

A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk

Jeanine M Genkinger, Donna Spiegelman, Kristin E Anderson, Leslie Bernstein, Piet A van den Brandt, Eugenia E Calle, Dallas R English, Aaron R Folsom, Jo L Freudenheim, Charles S Fuchs, Graham G Giles, Edward Giovannucci, Pamela L Horn-Ross, Susanna C Larsson, Michael Leitzmann, Satu Mannisto, James R Marshall, Anthony B Miller, Alpa V Patel, Thomas E Rohan Show all

International Journal of Cancer | WILEY | Published : 2011

Abstract

Epidemiologic studies of pancreatic cancer risk have reported null or nonsignificant positive associations for obesity, while associations for height have been null. Waist and hip circumference have been evaluated infrequently. A pooled analysis of 14 cohort studies on 846,340 individuals was conducted; 2,135 individuals were diagnosed with pancreatic cancer during follow-up. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were calculated by Cox proportional hazards models, and then pooled using a random effects model. Compared to individuals with a body mass index (BMI) at baseline between 21-22.9 kg/m(2) , pancreatic cancer risk was 47% higher (95%CI:23-75%) among ob..

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