Journal article
Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers
AC Antoniou, C Kartsonaki, OM Sinilnikova, P Soucy, L McGuffog, S Healey, A Lee, P Peterlongo, S Manoukian, B Peissel, D Zaffaroni, E Cattaneo, M Barile, V Pensotti, B Pasini, R Dolcetti, G Giannini, AL Putignano, L Varesco, P Radice Show all
Human Molecular Genetics | OXFORD UNIV PRESS | Published : 2011
DOI: 10.1093/hmg/ddr226
Abstract
Two single nucleotide polymorphisms (SNPs) at 6q25.1, near the ESR1 gene, have been implicated in the susceptibility to breast cancer for Asian (rs2046210) and European women (rs9397435). A genome-wide association study in Europeans identified two further breast cancer susceptibility variants: rs11249433 at 1p11.2 and rs999737 in RAD51L1 at 14q24.1. Although previously identified breast cancer susceptibility variants have been shown to be associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers, the involvement of these SNPs to breast cancer susceptibility in mutation carriers is currently unknown. To address this, we genotyped these SNPs in BRCA1 and BRCA2 mutation carriers ..
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Awarded by Fondazione Italiana per la Ricerca sul Cancro
Funding Acknowledgements
This work was supported by Cancer Research UK grants C12292/A11174 and C1287/A10118. The research leading to these results has received funding from the European Community's Seventh Framework Programme under grant agreement no. 223175 (HEALTH-F22009-223175).