Journal article

Second to fourth digit ratio (2D: 4D) and prostate cancer risk in the Melbourne Collaborative Cohort Study

DC Muller, GG Giles, JT Manning, JL Hopper, DR English, G Severi



BACKGROUND: The ratio of the lengths of index and ring fingers (2D:4D) is a marker of prenatal exposure to sex hormones, with low 2D:4D being indicative of high prenatal androgen action. Recent studies have reported a strong association between 2D:4D and risk of prostate cancer. METHODS: A total of 6258 men participating in the Melbourne Collaborative Cohort Study had 2D:4D assessed. Of these men, we identified 686 incident prostate cancer cases. Hazard ratios (HRs) and confidence intervals (CIs) were estimated for a standard deviation increase in 2D:4D. RESULTS: No association was observed between 2D:4D and prostate cancer risk overall (HRs 1.00; 95% CIs, 0.92-1.08 for right, 0.93-1.08 for ..

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study was funded by the National Health and Medical Research Council (Grant nos. 126402, 209057, 170215, 251533, 450104), and the infrastructure was provided by the Cancer Council Victoria. We would like to acknowledge the work of Juliet Anderson, Lily Laskaris and Judith Heads who measured the vast majority of the digits, and the past and present members of the study team. We thank the men of Melbourne who participated in this study and who still continue to participate in the Melbourne Collaborative Cohort Study.