Journal article
Chlamydia trachomatis infection and risk of cervical intraepithelial neoplasia
M Lehtinen, KA Ault, E Lyytikainen, J Dillner, SM Garland, DG Ferris, LA Koutsky, HL Sings, S Lu, RM Haupt, J Paavonen
Sexually Transmitted Infections | Published : 2011
Abstract
Objectives: High-risk human papillomavirus (hrHPV) is the primary cause of cervical cancer. As Chlamydia trachomatis is also linked to cervical cancer, its role as a potential co-factor in the development of cervical intraepithelial neoplasia (CIN) grade 2 or higher was examined. Methods: The placebo arms of two large, multinational, clinical trials of an HPV6/11/16/18 vaccine were combined. A total of 8441 healthy women aged 15-26 years underwent cervicovaginal cytology (Papanicolaou (Pap) testing) sampling and C trachomatis testing at day 1 and every 12 months thereafter for up to 4 years. Protocol-specified guidelines were used to triage participants with Pap abnormalities to colposcopy a..
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Funding Acknowledgements
[ "This study was funded by Merck Sharp & Dohme, Whitehouse Station, NJ.", "ML, KAA, JD, SMG, DGF and LAK have received funding through their institutions to conduct HPV vaccine studies for Merck. KAA has received consultancy and advisory board fees from Merck, and has received funding through his institution to conduct HPV-related research for Roche, Gen Probe and GlaxoSmithKline. JD has received consultancy fees, lecture fees and research grants from Merck and Sanofi Pasteur MSD. SMG has received advisory board fees and grant support from Commonwealth Serum Laboratories and GlaxoSmithKline, and lecture fees from Merck. DGF has received consultancy fees and funding through his institution to conduct HPV vaccine studies for GlaxoSmithKline, and lecture fees from Merck. JP has received consultancy fees and travel grants from Merck and GlaxoSmithKline. HLS, SL and RMH are employees of Merck and potentially own stock and/or stock options in the company." ]