Nuclear transit studies of patients with intractable chronic constipation reveal a subgroup with rapid proximal colonic transit

Abstract

Aims/Background: Nuclear transit studies (NTS) allow us to follow transit through the stomach and the small and large intestines. We identified children with chronic constipation with rapid proximal colonic transit and characterized their clinical features. Methods: We reviewed NTS from 1998 to 2009 to identify patients with chronic constipation and rapid proximal colonic transit, defined as greater than 25% of tracer beyond hepatic flexure at 6 hour and/or greater than 25% of tracer beyond end of descending colon at 24 hour. This was correlated with clinical symptoms and outcome from patient records. Results: Five hundred twenty children with chronic constipation underwent investigation by ..