Journal article
Histopathological correlation of 11C-choline PET scans for target volume definition in radical prostate radiotherapy
JH Chang, DL Joon, ST Lee, SJ Gong, AM Scott, ID Davis, D Clouston, D Bolton, CS Hamilton, V Khoo
Radiotherapy and Oncology | Published : 2011
Abstract
Background and purpose: To evaluate the accuracy of 11C-choline PET scans in defining dominant intraprostatic lesions (DILs) for radiotherapy target volume definition. Material and methods: Eight men with prostate cancer who had 11C-choline PET scans prior to radical prostatectomy were studied. Several methods were used to contour the DIL on the PET scans: visual, PET Edge, Region Grow, absolute standardised uptake value (SUV) thresholds and percentage of maximum SUV thresholds. Prostatectomy specimens were sliced in the transverse plane and DILs were delineated on these by a pathologist. These were then compared with the PET scans. The accuracy of correlation was assessed by the Dice simila..
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Funding Acknowledgements
I.D.D. is supported by a Victorian Cancer Agency Clinician Researcher Fellowship and is an honorary Australian National Health and Medical Research Council Practitioner Fellow. We are grateful to Graham Hepworth from the Statistical Consulting Centre, University of Melbourne for his advice regarding the statistical analyses and to Yin Peng Goh for her assistance with the image analyses.