Journal article
Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection
A Lim, A Amini, LJ D'Orsogna, R Rajasuriar, M Kramski, SR Lewin, DF Purcell, P Price, MA French
AIDS | Published : 2011
Abstract
Objectives: To examine the relationship between plasma markers of microbial translocation and antibodies to lipopolysaccharide (LPS) and circulating memory B cells in patients with HIV infection. Design: Cross-sectional study in antiretroviral therapy (ART)-naive (n=23) and ART-treated (n=27) HIV patients. Methods: Antibodies to LPS and immunoglobulins, assayed in stored serum, and matched memory B-cell counts were correlated with levels of LPS and bacterial 16S ribosome DNA (16S rDNA), assayed in stored plasma. Results: In ART-naive patients, plasma LPS levels correlated inversely with serum levels of IgG and IgA antibodies to LPS (P=0.03 and 0.006, respectively), serum levels of IgA anti-L..
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
Funding Acknowledgements
The authors thank Dr Zoltan Peterfi (University of Pecs) for his kind gift of LPS from Shigella sonnei Re4350 and his expertise in detection of LPS-specific antibodies. This study was funded by Project Grant 404 028 and Program Grant 510 488 from the National Health and Medical Research Council (NHMRC) of Australia. S. R. L. is an NHMRC Practitioner Fellow.