Journal article
Exploring the zoonotic potential of mycobacterium avium subspecies paratuberculosis through comparative genomics
JW Wynne, TJ Bull, T Seemann, DM Bulach, J Wagner, CD Kirkwood, WP Michalski
Plos One | Published : 2011
Abstract
A comparative genomics approach was utilised to compare the genomes of Mycobacterium avium subspecies paratuberculosis (MAP) isolated from early onset paediatric Crohn's disease (CD) patients as well as Johne's diseased animals. Draft genome sequences were produced for MAP isolates derived from four CD patients, one ulcerative colitis (UC) patient, and two non-inflammatory bowel disease (IBD) control individuals using Illumina sequencing, complemented by comparative genome hybridisation (CGH). MAP isolates derived from two bovine and one ovine host were also subjected to whole genome sequencing and CGH. All seven human derived MAP isolates were highly genetically similar and clustered togeth..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was funded by CSIRO and SGUL. Carl D. Kirkwood is supported by a Career Development Award Fellowship from the National Health and Medical Research Council of Australia (607347). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.